Only slight niggles - Sounblaster X-Fi working with glitches using a very old Voodoo kext, and Qfan not supported, so slightly 'enthusiastic' cooling policy. Almost scared to tinker too much now it's working, as I need a stable environment for emergency work.
Installers didn't work for me, I had to vanilla install on an intel i3, install nVidia Web Drivers then transplant to AMD. After that, boot from AMD 5.2 installer in safe mode to run post patches. Then reboot with CSM disabled, rebuild with Kext Utility then re-enabled CSM (optional). Boot flags: npci=0x3000 darkwake=0 slide=0 dart=0 EHCIacquire=Yes USBLegacyOff=Yes
nVidia GTX 1060 · 512Gb Samsung Pro 960 NVMe · X-Fi Titanium
240Gb Samsung Evo SSD · Windows 10 / OS X tbc